密歇根医科大学肿瘤和干细胞生物学研究博士后岗位
日期：2008-04-14
来源：丁香人才网
InstitutionUniversity of Michigan Medical SchoolPositionPostdoctoral Positions in Cancer and Stem Cell BiologyJob Number4003180Date PostedApr 9th 2008Application DeadlineOpen Until FilledDescriptionPo ...
Institution
University of Michigan Medical School
Position
Postdoctoral Positions in Cancer and Stem Cell Biology
Job Number
4003180
Date Posted
Apr 9th 2008
Application Deadline
Open Until Filled
Description
Postdoctoral positions are available for highly motivated individualswho are interested in using mouse genetics to study the role of tumorsuppressor genes in the normal stem cell function and tumorigenesis inthe central nervous system (CNS) and peripheral nervous system (PNS).Identification of cancer stem cells in human cancer suggests thatalterations in the self-renewal program of stem cells can lead totumorigenesis. However, direct evidence for a stem cell, a progenitorcell, or a fully differentiated cell is the cell-of-origin for most ofhuman cancers is still lacking. By employing genetically engineeredmouse tumor models, we have provided evidence that both stem cells anddifferentiated cells can serve as a cell-of-origin for nervous systemtumors (Zhu et al. Cancer Cell, 2005; Zheng et al., Cancer Cell, 2008).We are exploring the recently developed mouse models to study: (1) howtumor suppressor genes regulate the stem cell function includingself-renewal, survival, differentiation and migration, (2) howinactivation of tumor suppressor genes transforms neural stem cells orendow differentiated cells with stem cell characteristics, and (3) hownormal stem cells or differentiated cells become cancer stem cells.Further details of current research can be found at http://www.med.umich.edu/cdb/sub_pages/People/zhu.htm.
Interested candidates should send curriculum vitae & names andaddress of 3 references to:
Yuan Zhu, Ph.D.
Assistant Professor
Division of Molecular Medicine and Genetics
Departments of Internal Medicine and Cell & Developmental Biology
University of Michigan Medical School
2061, BSRB, 109 Zina Pitcher Pl
Ann Arbor, MI 48109-0638
Tel (O): 734-647-3033
Tel (lab): 734-647-0891
Email: yuanzhu@umich.edu
Representative Publications:
1. Zhu, Y., Romero, M., Ghosh, P., Ye, Z., Charnay, P., Rushing, E.J.,Marth, J.D. and Parada, L.F. (2001). Ablation of NF1 function in neuronsinduces abnormal development of cerebral cortex and reactive gliosis inthe brain. Genes & Development, 15:859-876.
2. Zhu, Y., Ghosh, P., Charnay, Burns, D.K. and Parada, L.F. (2002).Neurofibromas in NF1: Schwann cell origin and role of tumor environment.Science, 296: 920-922.
3. Zhu, Y., Guignard, F., Zhao, D., Liu, L., Burns, D. K., Mason, R. P.,and Parada, L. F (2005). Early inactivation of p53 tumor suppressor genecooperating with NF1 loss induces malignant astrocytoma. Cancer Cell, 8(2): 119-130.
4. Zhu, Y*., Harada, T., Liu, L., Lush, M.E., Guignard, F., Harada, C.,Burns, D.K., Bajenaru, M.L., Gutmann, D.H. and Parada, L.F. (2005).Inactivation of NF1 in CNS causes increased glial progenitorproliferation and optic glioma formation. Development, 132 (24): 5577-5588.
5. Zheng, H., Chang, L., Patel, N., Yang, J., Lowe, L., Burns, D.K. andZhu, Y. (2008). Induction of abnormal proliferation by non-myelinatingSchwann cells triggers neurofibroma formation. Cancer Cell, 13:117-128.
Contact
Yuan Zhu
Internal Medicine
University of Michigan Medical School
2061 BSRB
109 Zina Pitcher Pl
Ann Arbor, MI 48109-2200
United States
Phone: 734-647-3033
Email: yuanzhu umich.edu
Employer's Web Site: http://www.med.umich.edu/cdb/sub_pages/People/zhu.htm.
University of Michigan Medical School
Position
Postdoctoral Positions in Cancer and Stem Cell Biology
Job Number
4003180
Date Posted
Apr 9th 2008
Application Deadline
Open Until Filled
Description
Postdoctoral positions are available for highly motivated individualswho are interested in using mouse genetics to study the role of tumorsuppressor genes in the normal stem cell function and tumorigenesis inthe central nervous system (CNS) and peripheral nervous system (PNS).Identification of cancer stem cells in human cancer suggests thatalterations in the self-renewal program of stem cells can lead totumorigenesis. However, direct evidence for a stem cell, a progenitorcell, or a fully differentiated cell is the cell-of-origin for most ofhuman cancers is still lacking. By employing genetically engineeredmouse tumor models, we have provided evidence that both stem cells anddifferentiated cells can serve as a cell-of-origin for nervous systemtumors (Zhu et al. Cancer Cell, 2005; Zheng et al., Cancer Cell, 2008).We are exploring the recently developed mouse models to study: (1) howtumor suppressor genes regulate the stem cell function includingself-renewal, survival, differentiation and migration, (2) howinactivation of tumor suppressor genes transforms neural stem cells orendow differentiated cells with stem cell characteristics, and (3) hownormal stem cells or differentiated cells become cancer stem cells.Further details of current research can be found at http://www.med.umich.edu/cdb/sub_pages/People/zhu.htm.
Interested candidates should send curriculum vitae & names andaddress of 3 references to:
Yuan Zhu, Ph.D.
Assistant Professor
Division of Molecular Medicine and Genetics
Departments of Internal Medicine and Cell & Developmental Biology
University of Michigan Medical School
2061, BSRB, 109 Zina Pitcher Pl
Ann Arbor, MI 48109-0638
Tel (O): 734-647-3033
Tel (lab): 734-647-0891
Email: yuanzhu@umich.edu
Representative Publications:
1. Zhu, Y., Romero, M., Ghosh, P., Ye, Z., Charnay, P., Rushing, E.J.,Marth, J.D. and Parada, L.F. (2001). Ablation of NF1 function in neuronsinduces abnormal development of cerebral cortex and reactive gliosis inthe brain. Genes & Development, 15:859-876.
2. Zhu, Y., Ghosh, P., Charnay, Burns, D.K. and Parada, L.F. (2002).Neurofibromas in NF1: Schwann cell origin and role of tumor environment.Science, 296: 920-922.
3. Zhu, Y., Guignard, F., Zhao, D., Liu, L., Burns, D. K., Mason, R. P.,and Parada, L. F (2005). Early inactivation of p53 tumor suppressor genecooperating with NF1 loss induces malignant astrocytoma. Cancer Cell, 8(2): 119-130.
4. Zhu, Y*., Harada, T., Liu, L., Lush, M.E., Guignard, F., Harada, C.,Burns, D.K., Bajenaru, M.L., Gutmann, D.H. and Parada, L.F. (2005).Inactivation of NF1 in CNS causes increased glial progenitorproliferation and optic glioma formation. Development, 132 (24): 5577-5588.
5. Zheng, H., Chang, L., Patel, N., Yang, J., Lowe, L., Burns, D.K. andZhu, Y. (2008). Induction of abnormal proliferation by non-myelinatingSchwann cells triggers neurofibroma formation. Cancer Cell, 13:117-128.
Contact
Yuan Zhu
Internal Medicine
University of Michigan Medical School
2061 BSRB
109 Zina Pitcher Pl
Ann Arbor, MI 48109-2200
United States
Phone: 734-647-3033
Email: yuanzhu umich.edu
Employer's Web Site: http://www.med.umich.edu/cdb/sub_pages/People/zhu.htm.
微信扫一扫分享资讯
- 相关阅读
- 宝鸡高新医院招聘公告
- 宝鸡高新医院招聘公告
- 西安医学院附属宝鸡医院招聘公告（9月）
- 宝鸡市中心医院2021住院医师规培（补录）招生简章
- 西安医学院附属宝鸡医院2020年度招聘岗位需求
- 宝鸡市中心医院2019年住院医师规范化培训招生简章
怎样的简历标题可以打动 HR 的心？
如何在2秒钟内抓住HR的眼球，关键词很重要
合肥市口腔医院急聘口腔专业博士、硕士
安徽省内唯一一家三级口腔专科医院，创建于1956年，历经六十年的风雨兼程，已发展成为集医、教、研、防为一体的现代化口腔专科医院，并形成了“一院、两区、三部”的格局，现在面向全国急招口腔方面专业人才，欢迎您的投递！
热门职位
更多 >热门招聘单位
更多 >-
爱尔眼科·万州同城三院
0个职位正在招聘
-
西安先华康复医院
0个职位正在招聘
-
泰康健康产业投资控股有限公司北
0个职位正在招聘
-
杭州口腔医院集团富阳分院有限公
0个职位正在招聘
-
昆明眼科医院（有限公司）
0个职位正在招聘
