牛津大学帕金森氏病研究中心博士后岗位

Postdoctoral Career Development Fellow :
Dept of Physiology, Anatomy and Genetics, Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX

Employer:

University of Oxford

Website:

http://www.dpag.ox.ac.uk/job_opportunities

Location:

Dept of Physiology, Anatomy and Genetics, Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX

Posted:

December 17, 2009

Expires:

January 27, 2010

Jobs by tag(s):

molecular neurodegeneration, parkinsons disease, molecular neurobiology, neuropharmacology, physiology, anatomy , genetics, oxford, postdoc

Sites:

Naturejobs

Requisition number:

AV09034

job description:

Oxford Parkinson’s Disease Centre

University of Oxford

Postdoctoral Career Development Fellow (AV09034)

Five year fixed term post on Grade 7: Salary £28,839–£35,469 pa (with discretionary points to £38,757)

Generation of improved transgenic rodent models of Parkinson’s Disease

Applications are invited for a Postdoctoral Career Development Fellow to join the new multidisciplinary initiative, the Oxford Parkinson’s Disease Centre (OPDC) and undertake a highly collaborative and interdisciplinary project to develop improved transgenic rodent models of PD. The Fellow will be based in the Laboratory of Molecular Neurodegeneration in the Department of Physiology, Anatomy and Genetics, and will be supervised by Dr Richard Wade-Martins.

The Fellow will develop improve transgenic rodent (mice and rats) models of PD using bacterial artificial chromosome (BAC)-based transgenesis using wild-type and recombinant variants of genes previously identified within the OPDC as potential candidates underlying susceptibility to PD. BAC transgenics represent the state-of-the-art in transgenic mouse models as the correct temporal and spatial regulation of gene expression is retained in vivo. S/he will use homologous recombination in E. coli to generate mutant BAC constructs expressing PD-related genes. The vectors will be used to generate founder lines by pronuclear injection by Core Transgenic Services. The Fellow will be supported in this work by a full-time Research Assistant responsible for the management of the transgenic colonies. Lines with expression levels closely recapitulating those seen in human brain tissue will be taken forward for phenotypic analysis. We will use comparative gene expression profiling between neuronal subtypes in a healthy or disease state to provide important biological insights into molecular mechanisms of neurological diseases in affected neuronal populations. Finally, there will be opportunity to work closely with other members of the OPDC and have the opportunity to undertake further collaborative studies into the molecular pathology, behavioural phenotype and neuropharmacology of the new models generated. This Fellowship offers the opportunity to train in modern techniques in molecular neuroscience in the highly interdisciplinary research environment of the OPDC.

Applicants must have a PhD or equivalent, post-doctoral research experience in a relevant area of research, a good working knowledge of molecular and cellular biology, experience of working with mice or rats, enthusiasm for scientific research, and an interest in pre-clinical in vitro and in vivo models of neurological disease. A good publication record would be an advantage.

Further information about the Oxford Parkinson’s Disease Centre may be found at: http://opdc.medsci.ox.ac.uk

Informal enquiries may be directed to Dr Wade-Martins on richard.wade-martins@dpag.ox.ac.uk

The post-holder will be based in the Dept of Physiology, Anatomy and Genetics, Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX.

contact:

Further particulars and details of how to apply are available at www.dpag.ox.ac.uk/job_opportunities or email reference@dpag.ox.ac.uk

The post is funded by the Monument Discovery Award from the Parkinson’s Disease Society. The post is available immediately and is offered for a period of five years.

Interviews will be held on 16, 17 and 18 February 2010.

Please quote reference no: AV09034. The closing date for applications is noon on 27 January 2010.