瑞典卡罗琳斯卡研究所代谢学研究博士后岗位
日期：2007-12-18
来源：丁香人才网
InstitutionKarolinska Institutet (http://metabolomics.se)PositionPostdoctoral positions in metabolomicsLocationStockholm SwedenDate PostedDec 17th 2007DescriptionWe have two openings for individuals w ...
Institution
Karolinska Institutet (http://metabolomics.se)
Position
Postdoctoral positions in metabolomics
Location
Stockholm, Sweden
Date Posted
Dec 17th 2007
Description
We have two openings for individuals wishing to join a multidisciplinaryproject in the area of metabolomics. The overall aims of the project areto develop LC/MS-based methods for global eicosanoid profiling ofbronchial alveolar lavage fluid (BALF), plasma, atherosclerotic plaquesand other tissues. Developed methods will be employed in translationalresearch to probe a range of inflammatory diseases, including chronicobstructive pulmonary disease (COPD), asthma, and atherosclerosis. Thiswork will involve close collaboration with clinical researchers at theKarolinska University Hospital. Potential project expansion dependingupon the interests of the applicant includes development ofomics-integrating bioinformatics tools and pathway analysis incollaboration with the Kyoto University Bioinformatics Center(http://www.genome.jp/kegg/). Specific interests include development ofrelational database structures for use in systems biology approaches toinflammatory diseases. World class expertise and facilities in theseresearch areas exist at the Karolinska Institutet, including a ThermoLCQ Deca XP MAX ion-trap mass spectrometer equipped with an electrosprayion source, Thermo Surveyor LC system and 2 Agilent GC/MS systems. Thedepartment is also home to the Protein Analysis Center, which possess arange of advanced analytical instrumentation (http://www.mbb.ki.se/pac/index.html).
You should have a Ph.D. in mass spectrometry and/or bioanalyticalchemistry, with experience in small molecule mass spectrometry andbiological sample preparation techniques. Prior experience in lipidanalysis and bioinformatics is strongly preferred.
This position is initially available for 12 months, with potentialrenewal for an additional 12 months.
Start date: Funding is available from February 2008, but the start dateis negotiable.
Salary: Salary is stipend-based, includes health insurance, and isnegotiable depending upon applicant experience.
Contact
Send applications, including research experience, CV and at least tworeferences to Craig Wheelock at (craig.wheelock@metabolomics.se)
This project will be conducted in collaboration with Dr. Åsa Wheelockand Dr. Jesper Haeggström. For additional details of the departments andresearch interests:
http://www.metabolomics.se/
http://www.biomics.se/perspres.php?pers=120
http://www.mbb.ki.se
Interested candidates are referred to the following papers:
Martinez Molina D, Wetterholm A, Kohl A, McCarthy AA, Niegowski D,Ohlson E, Hammarberg T, Eshaghi S, Haeggstrom JZ, Nordlund P. Structuralbasis for synthesis of inflammatory mediators by human leukotriene C4synthase. Nature. 2007 448(7153):613-6.
Qiu H, Gabrielsen A, Agardh HE, Wan M, Wetterholm A, Wong CH, Hedin U,Swedenborg J, Hansson GK, Samuelsson B, Paulsson-Berne G, Haeggstrom JZ.Expression of 5-lipoxygenase and leukotriene A4 hydrolase in humanatherosclerotic lesions correlates with symptoms of plaque instability.Proc Natl Acad Sci U S A. 2006 103(21):8161-6.
Schmelzer KR, Wheelock AM, Dettmer K, Morin D and Hammock BD The role ofinflammatory mediators in the synergistic toxicity of ozone and1-nitronaphthalene in rat airways. Environ Health Perspect 2006 114(9):1354-60.
Wheelock CE, Goto S, Hammock BD, and Newman JW. Clofibrate-inducedchanges in the liver, heart, brain and white adipose lipid metabolome ofSwiss-Webster mice. Metabolomics 2007 3(2):137-45.
Karolinska Institutet (http://metabolomics.se)
Position
Postdoctoral positions in metabolomics
Location
Stockholm, Sweden
Date Posted
Dec 17th 2007
Description
We have two openings for individuals wishing to join a multidisciplinaryproject in the area of metabolomics. The overall aims of the project areto develop LC/MS-based methods for global eicosanoid profiling ofbronchial alveolar lavage fluid (BALF), plasma, atherosclerotic plaquesand other tissues. Developed methods will be employed in translationalresearch to probe a range of inflammatory diseases, including chronicobstructive pulmonary disease (COPD), asthma, and atherosclerosis. Thiswork will involve close collaboration with clinical researchers at theKarolinska University Hospital. Potential project expansion dependingupon the interests of the applicant includes development ofomics-integrating bioinformatics tools and pathway analysis incollaboration with the Kyoto University Bioinformatics Center(http://www.genome.jp/kegg/). Specific interests include development ofrelational database structures for use in systems biology approaches toinflammatory diseases. World class expertise and facilities in theseresearch areas exist at the Karolinska Institutet, including a ThermoLCQ Deca XP MAX ion-trap mass spectrometer equipped with an electrosprayion source, Thermo Surveyor LC system and 2 Agilent GC/MS systems. Thedepartment is also home to the Protein Analysis Center, which possess arange of advanced analytical instrumentation (http://www.mbb.ki.se/pac/index.html).
You should have a Ph.D. in mass spectrometry and/or bioanalyticalchemistry, with experience in small molecule mass spectrometry andbiological sample preparation techniques. Prior experience in lipidanalysis and bioinformatics is strongly preferred.
This position is initially available for 12 months, with potentialrenewal for an additional 12 months.
Start date: Funding is available from February 2008, but the start dateis negotiable.
Salary: Salary is stipend-based, includes health insurance, and isnegotiable depending upon applicant experience.
Contact
Send applications, including research experience, CV and at least tworeferences to Craig Wheelock at (craig.wheelock@metabolomics.se)
This project will be conducted in collaboration with Dr. Åsa Wheelockand Dr. Jesper Haeggström. For additional details of the departments andresearch interests:
http://www.metabolomics.se/
http://www.biomics.se/perspres.php?pers=120
http://www.mbb.ki.se
Interested candidates are referred to the following papers:
Martinez Molina D, Wetterholm A, Kohl A, McCarthy AA, Niegowski D,Ohlson E, Hammarberg T, Eshaghi S, Haeggstrom JZ, Nordlund P. Structuralbasis for synthesis of inflammatory mediators by human leukotriene C4synthase. Nature. 2007 448(7153):613-6.
Qiu H, Gabrielsen A, Agardh HE, Wan M, Wetterholm A, Wong CH, Hedin U,Swedenborg J, Hansson GK, Samuelsson B, Paulsson-Berne G, Haeggstrom JZ.Expression of 5-lipoxygenase and leukotriene A4 hydrolase in humanatherosclerotic lesions correlates with symptoms of plaque instability.Proc Natl Acad Sci U S A. 2006 103(21):8161-6.
Schmelzer KR, Wheelock AM, Dettmer K, Morin D and Hammock BD The role ofinflammatory mediators in the synergistic toxicity of ozone and1-nitronaphthalene in rat airways. Environ Health Perspect 2006 114(9):1354-60.
Wheelock CE, Goto S, Hammock BD, and Newman JW. Clofibrate-inducedchanges in the liver, heart, brain and white adipose lipid metabolome ofSwiss-Webster mice. Metabolomics 2007 3(2):137-45.
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