英国布里斯托大学膜生物物理学博士后岗位
日期：2008-05-20
来源：丁香人才网
InstitutionUniversity of Bristol (http://www.bristol.ac.uk)PositionPostdoctoral Research Assistant in Membrane Biophysics/ChemistryLocationBristol UKDate PostedMay 16th 2008Date ExpiresJune 3th 2008Ta ...
Institution
University of Bristol (http://www.bristol.ac.uk)
Position
Postdoctoral Research Assistant in Membrane Biophysics/Chemistry
Location
Bristol, UK
Date Posted
May 16th 2008
Date Expires
June 3th 2008
Tags
postdoctoral research assistant, biophysics, chemistry, bristol, and uk
Description
This post is available in the groups of Prof. A. P. Davis, School ofChemistry, and Dr. D. N. Sheppard, Department of Physiology andPharmacology, on the EPSRC-funded project: “Synthetic Anion Carriers forBiomedical Applications”. Anion transport across membranes is a keybiological process, vital for the health of cells and organisms.Dysfunctional anion transport (usually due to faulty anion channels) isthe root cause of several genetic diseases, the most common being cysticfibrosis. Molecules which promote chloride transport across membranescould serve as treatments for these diseases, and would certainly beuseful tools for research. We have developed a family of powerful anionreceptors which show good activity as chloride transporters. In this newproject we aim to understand and optimise the system, and to test thetransporters in natural membranes and cells, with a view to developingtherapeutic applications.
As part of the project team, we seek a membrane biophysicist or chemistwho will play the major role in testing the transporters andcharacterising their mechanism of action. The main technique used willbe electrical measurements in planar lipid bilayers (PLBs, or blacklipid membranes), but the patch-clamp method will also be used to studytransporters incorporated into giant liposomes. Studies in syntheticvesicles, and in natural membranes (patch-clamp electrophysiology andUssing chamber technique), will also be performed. You will ideally haveexpertise in mechanistic studies of ion transport across natural andsynthetic membranes using the PLB or patch-clamp techniques, and abackground in either cell physiology or membrane chemistry. Experiencein the study of synthetic ion transporters would be especiallyadvantageous. You must be able to work closely with other members of theteam, especially with a synthetic supramolecular chemist who willprovide materials and collaborate on testing. The position is availablefor three years, subject to satisfactory progress. The starting date isnegotiable, but must be no later than 31 October 2008.
For further information on the research groups see:http://www.chm.bris.ac.uk/staff/adavis.htm and http://www.bristol.ac.uk/phys-pharm/staffResearch/staffResearch.php?id=44
If successful, you may be appointed either on a fixed term or apermanent contract depending on the extent of your previous relevantresearch experience. Further information can be found at http://www.bristol.ac.uk/personnel/ftc/
University of Bristol (http://www.bristol.ac.uk)
Position
Postdoctoral Research Assistant in Membrane Biophysics/Chemistry
Location
Bristol, UK
Date Posted
May 16th 2008
Date Expires
June 3th 2008
Tags
postdoctoral research assistant, biophysics, chemistry, bristol, and uk
Description
This post is available in the groups of Prof. A. P. Davis, School ofChemistry, and Dr. D. N. Sheppard, Department of Physiology andPharmacology, on the EPSRC-funded project: “Synthetic Anion Carriers forBiomedical Applications”. Anion transport across membranes is a keybiological process, vital for the health of cells and organisms.Dysfunctional anion transport (usually due to faulty anion channels) isthe root cause of several genetic diseases, the most common being cysticfibrosis. Molecules which promote chloride transport across membranescould serve as treatments for these diseases, and would certainly beuseful tools for research. We have developed a family of powerful anionreceptors which show good activity as chloride transporters. In this newproject we aim to understand and optimise the system, and to test thetransporters in natural membranes and cells, with a view to developingtherapeutic applications.
As part of the project team, we seek a membrane biophysicist or chemistwho will play the major role in testing the transporters andcharacterising their mechanism of action. The main technique used willbe electrical measurements in planar lipid bilayers (PLBs, or blacklipid membranes), but the patch-clamp method will also be used to studytransporters incorporated into giant liposomes. Studies in syntheticvesicles, and in natural membranes (patch-clamp electrophysiology andUssing chamber technique), will also be performed. You will ideally haveexpertise in mechanistic studies of ion transport across natural andsynthetic membranes using the PLB or patch-clamp techniques, and abackground in either cell physiology or membrane chemistry. Experiencein the study of synthetic ion transporters would be especiallyadvantageous. You must be able to work closely with other members of theteam, especially with a synthetic supramolecular chemist who willprovide materials and collaborate on testing. The position is availablefor three years, subject to satisfactory progress. The starting date isnegotiable, but must be no later than 31 October 2008.
For further information on the research groups see:http://www.chm.bris.ac.uk/staff/adavis.htm and http://www.bristol.ac.uk/phys-pharm/staffResearch/staffResearch.php?id=44
If successful, you may be appointed either on a fixed term or apermanent contract depending on the extent of your previous relevantresearch experience. Further information can be found at http://www.bristol.ac.uk/personnel/ftc/
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